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Si el grado de la irritación local lo justifica, se debe indicar al paciente usar menos frecuentemente RETIN-A o suspender el tratamiento totalmente.

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Potential mechanisms for disulfiram-associated neurotoxicity include abnormal CNS metal accumulation from the chelation of copper by DDC, leading to free radical formation and neuronal oxidative stress. You can also manage medical PAs if your patient’s health plan is part of Care Continuum 1!

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